Advanced Clinical Trials and Prospective Observational Studies
This course introduces more advanced concepts in designing and analysing clinical trials and prospective observational studies.
|Faculty||Faculty of Health and Medicine|
|School||School of Medicine and Public Health|
Not currently offered
On successful completion of this course, students will be able to:
Conducting sound clinical research is a foundational pillar of medicine. Students will be exposed to modern methods for conducting clinical research. Topics presented will include: Futility analysis, stochastic curtailment, group sequential methods, Lan-Demets alpha-spending function, O’Brien-Fleming bounds, computation of conditional power, gatekeeper methods, sequential monitoring, missing by design biomarker clinical trials, equivalence and non-inferiority trials, imputation using the EM algorithm, power analysis for multiple endpoint studies, fuzzy-set and propensity score matching algorithms for observational studies, sources of and methods for handling non-randomisation bias, closed-testing and permutation procedures for multiplicity adjustment, sacrificial matched-set designs, alternative surrogate endpoints for primary clinical endpoints, cross-over trials, stepped wedge trials, multiple baseline studies, block randomisation with random block sizes, adaptive 2-stage clinical trials, cluster randomisation, and tests for trend and dose response.
|Contact Hours||Not currently offered|
|Timetable||2017 Course Timetables for BIOS6141|